Clinical Research shows that Chinese Herbal Medicine can increase pregnancy rates
K Ried’s team performed a systematic review in 2011 looking at the use of Chinese herbal medicine in infertility treatment. They identified eight randomised controlled trials (RCTs), 13 cohort studies, three case series, and six case studies involving 1851 women suffering from infertility. Meta-analysis of the RCTs suggested a 3.5 greater likelihood of achieving pregnancy with Chinese Herbal Medicine therapy over a four-month period compared with Western drug (clomiphene) therapy alone. They suggested that management of female infertility with Chinese Herbal Medicine could improve pregnancy rates two-fold. They also found that assessment of the quality of the menstrual cycle, integral to TCM diagnosis, appears to be fundamental to successful treatment of female infertility.
The same group published an updated review of the same topic in 2015, where they collected data from 40 RCTs involving 4247 women suffering from infertility into a systematic review. In this study meta-analysis suggested a 1.74 higher probability of achieving pregnancy with CHM therapy than with Western therapy alone. In addition the authors concluded that fertility indicators such as ovulation rates, cervical mucus scores, biphasic basal body temperatures, and appropriate thickness of the endometrial linings are positively influenced by CHM therapy, indicating an ameliorating physiological effect for viable pregnancy.
There are many studies which aim to elucidate the mechanism of Chinese Herbal Medicine in the treatment of conditions frequently associated with infertility. The following are some of the underlying mechanisms associated with the efficacy of herbal medicine treatment.
Yu Nan, Yang Jing, Yin T (2011) Extracts from a traditional Chinese herbal remedy (Zhuyun recipe) improve endometrial receptivity in mice with embryonic implantation dysfunction and ovulation stimulation. J Ethnopharmacol 137(1): 389-395.
X Gong, Lou J, Lu Q, Huang H, Jin Z (2015) Bu Shen HuoXue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model. Exp Ther Med 9(3): 751-756.
S Li, S Luo (2010) Study on Kidney Tonifying of CHM to the Rat Models with Ovulated inhibition, Chinese Journal of Basic Medicine in TCM 16 (7): 567-569.
X Teng, et al. (2016) Study on mechanism of regulation and control of Yulin formula of CHM to hormone level and histomorphology of SD rat model of premature ovary failure. Assay of Master degree of TCM gynaecology, BUCM, China.
H Zhao, S Luo, et al. (2008) Effects of Zhuyun No3 Serum TG-Bl in Abortion Rats of Kidney Deficiency and Luteum Inhibition Shanghai. Journal of TCM 42(12): 71-73.
H Du, Chang X, Du H, Zhang M, Zhang J, et al. (2013) Effect of soothing liver therapy on oocyte quality and growth differentiation factor-9 in patients undergoing in vitro fertilization and embryo transfer. J Tradit Chin Med 33(5): 597-602.